![]() ![]() "In light of the positive results regarding the neutralization of venom from the monocled cobra, we mimicked a true rescue situation, injecting mice with cobra venom and then administering the antibody. For the monocled cobra specifically, the antibody completely prevented lethality in envenomed mice. Subsequent in vivo studies showed that the antibody prevented or delayed death from venom. It bound to various neurotoxins present in the venoms of the monocled cobra, the forest cobra, the spectacled cobra, the king cobra, the black mamba, and the many-banded krait. He founded IONTAS and has recently established a new anti-venom group at the University of Cambridge.ĭeliberately selecting hundreds of antibody candidates and testing the most promising against toxins in different snake venoms, the researchers found that one in particular (2554_01_D11) was especially potent and broadly neutralizing. I am delighted to be involved in these efforts to direct phage display technology to the blight of snakebite envenomation," says John McCafferty, the inventor of antibody phage display. "There has been a revolution in recombinant antibody technology over the last three decades. They use phage display technology, a popular in vitro methodology within drug discovery, to select antibodies that bind well to the toxins in the venom, enabling broad neutralization. ![]() In essence, their approach is to develop antibodies of fully human origin, which offer fewer adverse reactions, competitive costs, and, when fine-tuned, superior efficacy. New antibody works against several neurotoxins Their work is published in Nature Communications. He conducted the research with colleagues at DTU, ETH Zurich, Universidad de Costa Rica, and industrial partners Sophion Bioscience and IONTAS. It could provide the basis for more effective treatments for snakebite victims in the future," says Andreas Hougaard Laustsen-Kiel, a professor at DTU Bioengineering. This broadened cross-neutralization capacity is very promising. "We have previously developed antibodies against the venom toxins from single snake species however, our new results demonstrate that our technology has great potential in neutralizing toxins from multiple species, even from different continents. Recently, an international team of scientists led by DTU reached remarkable results and developed a new modernized prototype treatment that proves effective against the venom of African and Asian elapid snakes, such as some cobra, mamba, and krait species - many of which are among the world's deadliest. So, the search for novel ways to treat severe snakebite envenoming is ongoing. Although they are proven effective, these medicines may cause adverse reactions that can sometimes be severe. For 128 years, our primary treatment against snakebite has been using mixtures of polyclonal antibodies derived from immunized animal blood.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |